Mutation-Independent Gene Therapies for Rod-Cone Dystrophies.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-75402-4_10
Abstract: The clinical success of gene replacement therapies in recent years has served as a proof of concept for the treatment of inherited retinal degenerations using adeno-associated virus (AAV) as viral vector. However, inherited retinal degenerative… read more here.
Keywords: mutation independent; cone dystrophies; rod cone; gene ... See more keywords
Gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors
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DOI: 10.1038/cr.2017.57
Abstract: Gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors read more here.
Keywords: therapy via; crispr cas9; mutation independent; independent therapy ... See more keywords
Cholesterol esterification inhibition and imatinib treatment synergistically inhibit growth of BCR-ABL mutation-independent resistant chronic myelogenous leukemia
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DOI: 10.1371/journal.pone.0179558
Abstract: Since the advent of tyrosine kinase inhibitors (TKIs) such as imatinib, nilotinib, and dasatinib, chronic myelogenous leukemia (CML) prognosis has improved greatly. However, ~30–40% of patients develop resistance to imatinib therapy. Although most resistance is… read more here.
Keywords: cml; mutation independent; abl mutation; bcr abl ... See more keywords
miR‐181a/b downregulation: a mutation‐independent therapeutic approach for inherited retinal diseases
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202215941
Abstract: Inherited retinal diseases (IRDs) are a group of diseases whose common landmark is progressive photoreceptor loss. The development of gene‐specific therapies for IRDs is hampered by their wide genetic heterogeneity. Mitochondrial dysfunction is proving to… read more here.
Keywords: mir 181a; inherited retinal; mutation independent; retinal diseases ... See more keywords