BindProfX: Assessing Mutation-Induced Binding Affinity Change by Protein Interface Profiles with Pseudo-Counts.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2016.11.022
Abstract: Understanding how gene-level mutations affect the binding affinity of protein-protein interactions is a key issue of protein engineering. Due to the complexity of the problem, using physical force field to predict the mutation-induced binding free-energy… read more here.
Keywords: protein; mutation induced; change; binding affinity ... See more keywords
Virus-like Plasmonic Nanoprobes for Quick Analysis of Antiviral Efficacy and Mutation-Induced Drug Resistance.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c05464
Abstract: As the pathogenic viruses and the variants of concern greatly threaten human health and global public safety, the development of convenient and robust strategies enabling rapid analysis of antiviral drug efficacy and mutation-induced resistance is… read more here.
Keywords: mutation induced; efficacy; like plasmonic; drug ... See more keywords
Mutation-induced alterations of intra-filament subunit organization in vimentin filaments revealed by SAXS.
Sign Up to like & getrecommendations! Published in 2019 at "Soft matter"
DOI: 10.1039/c8sm02281j
Abstract: Vimentin intermediate filaments constitute a distinct filament system in mesenchymal cells that is instrumental for cellular mechanics and migration. In vitro, the rod-like monomers assemble in a multi-step, salt-dependent manner into micrometer long biopolymers. To… read more here.
Keywords: vimentin; mutation induced; vimentin filaments; intra filament ... See more keywords
Bioinformatics toolbox for exploring target mutation-induced drug resistance
Sign Up to like & getrecommendations! Published in 2023 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbad033
Abstract: Drug resistance is increasingly among the main issues affecting human health and threatening agriculture and food security. In particular, developing approaches to overcome target mutation-induced drug resistance has long been an essential part of biological… read more here.
Keywords: mutation induced; induced drug; target mutation; drug ... See more keywords
MutaRNA: analysis and visualization of mutation-induced changes in RNA structure
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa331
Abstract: Abstract RNA molecules fold into complex structures as a result of intramolecular interactions between their nucleotides. The function of many non-coding RNAs and some cis-regulatory elements of messenger RNAs highly depends on their fold. Single-nucleotide… read more here.
Keywords: induced changes; mutation induced; structure; changes rna ... See more keywords
Bioinformatics analysis of microarray data to explore the key genes involved in HSF4 mutation-induced cataract.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2018.06.03
Abstract: AIM To reveal the mechanisms of heat-shock transcription factor 4 (HSF4) mutation-induced cataract. METHODS GSE22362, including 3 HSF4-null lens and 3 wild-type lens, was obtained from Gene Expression Omnibus database. After data preprocessing, the differentially… read more here.
Keywords: network; mutation induced; mmu mir; hsf4 mutation ... See more keywords
Conformational Flexibility and Local Frustration in the Functional States of the SARS-CoV-2 Spike B.1.1.7 and B.1.351 Variants: Mutation-Induced Allosteric Modulation Mechanism of Functional Dynamics and Protein Stability
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031646
Abstract: Structural and functional studies of the SARS-CoV-2 spike proteins have recently determined distinct functional states of the B.1.1.7 and B.1.351 spike variants, providing a molecular framework for understanding the mechanisms that link the effect of… read more here.
Keywords: frustration; mutation induced; sars cov; cov spike ... See more keywords
The Denaturant- and Mutation-Induced Disassembly of Pseudomonas aeruginosa Hexameric Hfq Y55W Mutant
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27123821
Abstract: Although oligomeric proteins are predominant in cells, their folding is poorly studied at present. This work is focused on the denaturant- and mutation-induced disassembly of the hexameric mutant Y55W of the Qβ host factor (Hfq)… read more here.
Keywords: denaturant mutation; mutation induced; y55w; induced disassembly ... See more keywords