The somatic mutation landscape of premalignant colorectal adenoma
Sign Up to like & getrecommendations! Published in 2017 at "Gut"
DOI: 10.1136/gutjnl-2016-313573
Abstract: Objective There are few studies which characterised the molecular alterations in premalignant colorectal adenomas. Our major goal was to establish colorectal adenoma genome atlas and identify molecular markers of progression from colorectal adenoma to adenocarcinoma.… read more here.
Keywords: mutation landscape; adenoma; somatic mutation; premalignant colorectal ... See more keywords
Abstract 6087: Mutation and co-mutation landscape ofERBB2 alterations in advanced NSCLC
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DOI: 10.1158/1538-7445.am2023-6087
Abstract: Background: ERBB2 (HER2) insertions and point mutations are oncogenic drivers in non-small cell lung cancer (NSCLC) and now has approved targeted therapy for this patient population. Here, we present the landscape of ERBB2 genetic alterations… read more here.
Keywords: mutation landscape; mutation mutation; landscape oferbb2; mutation ... See more keywords
The somatic mutation landscape of the human body
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DOI: 10.1186/s13059-019-1919-5
Abstract: BackgroundSomatic mutations in healthy tissues contribute to aging, neurodegeneration, and cancer initiation, yet they remain largely uncharacterized.ResultsTo gain a better understanding of the genome-wide distribution and functional impact of somatic mutations, we leverage the genomic… read more here.
Keywords: human body; mutation landscape; somatic mutation; tissue ... See more keywords
Mutation landscape and intra-tumor heterogeneity of two MANECs of the esophagus revealed by multi-region sequencing
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DOI: 10.18632/oncotarget.18678
Abstract: Mixed adenoneuroendocrine carcinoma (MANEC) in the esophagus is an infrequent but highly malignant cancer with few known genomic alterations. We conducted whole-exome sequencing and whole-genome SNP genotyping for 4-6 tumor subregions and 5-6 adjacent normal… read more here.
Keywords: tumor; mutation landscape; heterogeneity; intra tumor ... See more keywords