LAUSR

Mutation patterns identify adult patients with de novo acute myeloid leukemia aged 60 years or older who respond favorably to standard chemotherapy: an analysis of Alliance studies

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0 Published in 2018 at "Leukemia"

DOI: 10.1038/s41375-018-0068-2

Abstract: Thus far, only 5–15% of AML patients aged ≥60 years are cured with chemotherapy. Identification of patients who are less (more) likely to respond to standard chemotherapy might enable early risk stratification toward alternative treatment… read more here.

Keywords: risk; aged years; patients novo; standard chemotherapy ... See more keywords

A model for RAS mutation patterns in cancers: finding the sweet spot

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1 Published in 2018 at "Nature Reviews Cancer"

DOI: 10.1038/s41568-018-0076-6

Abstract: The three RAS genes — HRAS, NRAS and KRAS — are collectively mutated in one-third of human cancers, where they act as prototypic oncogenes. Interestingly, there are rather distinct patterns to RAS mutations; the isoform… read more here.

Keywords: ras mutation; model ras; mutation patterns; sweet spot ... See more keywords

Association of Neisseria gonorrhoeae genogroups and specific PBP2/MtrR/PorB mutation patterns with susceptibility to penicillin in a susceptible gonococcal population

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0 Published in 2018 at "Journal of Antimicrobial Chemotherapy"

DOI: 10.1093/jac/dky233

Abstract: Objectives To ascertain whether the antimicrobial susceptibility of Neisseria gonorrhoeae isolates with differing susceptibilities to penicillin is associated with genogroups (GGs) and combined mutation patterns in PBP2 (penA), the multiple transfer resistance repressor (MtrR; mtrR)… read more here.

Keywords: mutation patterns; susceptibility; mutation; mtrr porb ... See more keywords

Mutation patterns of resistance genes for macrolides, aminoglycosides, and rifampicin in non-tuberculous mycobacteria isolates from Kenya

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1 Published in 2022 at "F1000Research"

DOI: 10.12688/f1000research.124002.5

Abstract: Background: Non-tuberculous mycobacteria (NTM) treatment constitutes a macrolide-based antibiotic regimen in combination with aminoglycosides for Rapid-Growing Mycobacteria (RGM), and rifampicin for Slow-Growing Mycobacteria (SGM). Mutations in the anti-NTM drug target regions promote NTM evolution to… read more here.

Keywords: tuberculous mycobacteria; mutation patterns; resistance; non tuberculous ... See more keywords