BnpC: Bayesian non-parametric clustering of single-cell mutation profiles
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaa599
Abstract: Abstract Motivation The high resolution of single-cell DNA sequencing (scDNA-seq) offers great potential to resolve intratumor heterogeneity (ITH) by distinguishing clonal populations based on their mutation profiles. However, the increasing size of scDNA-seq datasets and… read more here.
Keywords: single cell; mutation profiles; scdna seq; non parametric ... See more keywords
Clinical outcomes of women with ovarian metastases of colorectal cancer treated with oophorectomy with respect to their somatic mutation profiles
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.24735
Abstract: We clarified the clinical prevalence of ovarian metastases from colorectal cancers (CRCs) in 296 female patients with CRC and evaluated clinical outcomes with relation to their mutational profiles, such as BRAF/KRAS mutation and microsatellite instability… read more here.
Keywords: ovarian metastases; clinical outcomes; metastases colorectal; mutation profiles ... See more keywords
Somatic Mutation Profiles Revealed by Next Generation Sequencing (NGS) in 39 Chinese Hepatocellular Carcinoma Patients
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.800679
Abstract: The features and significance of somatic mutation profiles in hepatocellular carcinoma (HCC) have not been completely elucidated to date. In this study, 39 tumor specimens from HCC patients were collected for gene variation analysis by… read more here.
Keywords: hepatocellular carcinoma; somatic mutation; mutation profiles; next generation ... See more keywords
Mutation Profiles of Ovarian Seromucinous Borderline Tumors in Japanese Patients
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DOI: 10.3390/curroncol29050294
Abstract: Ovarian seromucinous tumors (SMBTs) are relatively rare, and their carcinogenesis is largely unknown. In this study, the molecular features of SMBTs in Japan are assessed. DNA was extracted from microdissected paraffin-embedded sections from 23 SMBT… read more here.
Keywords: ovarian seromucinous; kras braf; braf pik3ca; loss ... See more keywords