MIRAGE Syndrome: Phenotypic Rescue by Somatic Mutation and Selection.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2019.08.008
Abstract: MIRAGE syndrome, a multisystem disorder, results from heterozygous gain-of-function mutations in SAMD9, which encodes a growth suppressor, located on chromosome 7. Somatic changes involving loss-of-function mutations of the altered SAMD9 allele or loss of chromosome… read more here.
Keywords: somatic mutation; mutation selection; mirage syndrome; phenotypic ... See more keywords
A mutation-selection model of protein evolution under persistent positive selection.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology and evolution"
DOI: 10.1093/molbev/msab309
Abstract: We use first principles of population genetics to model the evolution of proteins under persistent positive selection (PPS). PPS may occur when organisms are subjected to persistent environmental change, during adaptive radiations, or in host-pathogen… read more here.
Keywords: evolution; positive selection; persistent positive; selection ... See more keywords
An Improved Codon Modeling Approach for Accurate Estimation of the Mutation Bias
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msac005
Abstract: Abstract Phylogenetic codon models are routinely used to characterize selective regimes in coding sequences. Their parametric design, however, is still a matter of debate, in particular concerning the question of how to account for differing… read more here.
Keywords: mutation selection; nucleotide composition; mutation; approach ... See more keywords