Mutation spectra of the BRCA1/2 genes in human breast and ovarian cancer and germline
Sign Up to like & getrecommendations! Published in 2024 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22614
Abstract: Annotating genomic sequence alterations is sometimes a difficult decision, particularly in missense variants with uncertain pathogenic significance and also in those presumed as germline pathogenic variants. We here suggest that mutation spectrum may also be… read more here.
Keywords: cancer; germline; breast; mutation spectra ... See more keywords
Variation in Mutation Spectra Among CRISPR/Cas9 Mutagenized Poplars
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2018.00594
Abstract: In an effort to produce reliably contained transgenic trees, we used the CRISPR/Cas9 system to alter three genes expected to be required for normal flowering in poplar (genus Populus). We designed synthetic guide RNAs (sgRNAs)… read more here.
Keywords: sgrna; crispr cas9; spectra among; mutation spectra ... See more keywords