Discovery of 2-Amino-7-sulfonyl-7H-pyrrolo[2,3-d]pyrimidine Derivatives as Potent Reversible FGFR Inhibitors with Gatekeeper Mutation Tolerance: Design, Synthesis, and Biological Evaluation.
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DOI: 10.1021/acs.jmedchem.2c01420
Abstract: Fibroblast growth factor receptors (FGFRs) play key roles in promoting cancer cell proliferation, differentiation, and migration. However, acquired resistance to FGFR inhibitors has become an emerging challenge in long-term cancer therapies, especially for hepatocellular carcinoma… read more here.
Keywords: sulfonyl pyrrolo; amino sulfonyl; fgfr inhibitors; pyrrolo pyrimidine ... See more keywords
Prioritization of Variants Detected by Next Generation Sequencing According to the Mutation Tolerance and Mutational Architecture of the Corresponding Genes
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DOI: 10.3390/ijms19061584
Abstract: The biggest challenge geneticists face when applying next-generation sequencing technology to the diagnosis of rare diseases is determining which rare variants, from the dozens or hundreds detected, are potentially implicated in the patient’s phenotype. Thus,… read more here.
Keywords: prioritization; mutation tolerance; mutation; mutational architecture ... See more keywords
Different Mutation Tolerance of Lentiviral (HIV-1) and Deltaretroviral (BLV and HTLV) Protease Precursors
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DOI: 10.3390/v14091888
Abstract: The bovine leukemia virus (BLV) and the human T-lymphothropic viruses (HTLVs) are members of the deltaretrovirus genus of Retroviridae family. An essential event of the retroviral life cycle is the processing of the polyproteins by… read more here.
Keywords: hiv; protease; blv; blv htlv ... See more keywords