Level of neo-epitope predecessor and mutation type determine T cell activation of MHC binding peptides
Sign Up to like & getrecommendations! Published in 2019 at "Journal for Immunotherapy of Cancer"
DOI: 10.1186/s40425-019-0595-z
Abstract: BackgroundTargeting epitopes derived from neo-antigens (or “neo-epitopes”) represents a promising immunotherapy approach with limited off-target effects. However, most peptides predicted using MHC binding prediction algorithms do not induce a CD8 + T cell response, and there is… read more here.
Keywords: binding peptides; mutation type; mhc binding; neo epitope ... See more keywords
Effect of Mutation Type on Ectopic Ossification Among Adult Patients With X-Linked Hypophosphatemia
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DOI: 10.1210/jendso/bvae184
Abstract: Abstract Context Causative factors for ectopic ossifications in X-linked hypophosphatemia (XLH) remain to be elucidated. Objective This work aimed to investigate the genotype-phenotype correlations between the phosphate-regulating endopeptidase homologue, X-linked gene (PHEX) and ectopic ossifications… read more here.
Keywords: ectopic ossification; linked hypophosphatemia; ossification; type ectopic ... See more keywords