Articles with "mutation type" as a keyword



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Level of neo-epitope predecessor and mutation type determine T cell activation of MHC binding peptides

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Published in 2019 at "Journal for Immunotherapy of Cancer"

DOI: 10.1186/s40425-019-0595-z

Abstract: BackgroundTargeting epitopes derived from neo-antigens (or “neo-epitopes”) represents a promising immunotherapy approach with limited off-target effects. However, most peptides predicted using MHC binding prediction algorithms do not induce a CD8 + T cell response, and there is… read more here.

Keywords: binding peptides; mutation type; mhc binding; neo epitope ... See more keywords