Level of neo-epitope predecessor and mutation type determine T cell activation of MHC binding peptides
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DOI: 10.1186/s40425-019-0595-z
Abstract: BackgroundTargeting epitopes derived from neo-antigens (or “neo-epitopes”) represents a promising immunotherapy approach with limited off-target effects. However, most peptides predicted using MHC binding prediction algorithms do not induce a CD8 + T cell response, and there is… read more here.
Keywords: binding peptides; mutation type; mhc binding; neo epitope ... See more keywords