Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach
Sign Up to like & getrecommendations! Published in 2021 at "VirusDisease"
DOI: 10.1007/s13337-021-00720-4
Abstract: The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) is spreading, as the causative pathogen of coronavirus disease-19 (COVID-19). It has infected more than 1.65 billion people all over the world since it was discovered and… read more here.
Keywords: protein; mutational analysis; spike protein; sars cov ... See more keywords
Diagnostic and therapeutic implications of genetic heterogeneity in myeloid neoplasms uncovered by comprehensive mutational analysis
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia Research Reports"
DOI: 10.1016/j.lrr.2017.09.001
Abstract: While growing use of comprehensive mutational analysis has led to the discovery of innumerable genetic alterations associated with various myeloid neoplasms, the under-recognized phenomenon of genetic heterogeneity within such neoplasms creates a potential for diagnostic… read more here.
Keywords: myeloid neoplasms; genetic heterogeneity; analysis; mutational analysis ... See more keywords
Phylogenetic diversity and mutational analysis of New Delhi Metallo-β-lactamase (NDM) producing E. coli strains from pediatric patients in Pakistan
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2021.06.037
Abstract: The evolution of NDM genes (blaNDM) in E. coli is accounted for expansive multidrug resistance (MDR), causing severe infections and morbidities in the pediatric population. This study aimed to analyze the phylogeny and mutations in… read more here.
Keywords: phylogenetic diversity; analysis; blandm; blandm blandm ... See more keywords
Mutational analysis of gene function in the Anaplasmataceae: Challenges and perspectives.
Sign Up to like & getrecommendations! Published in 2019 at "Ticks and tick-borne diseases"
DOI: 10.1016/j.ttbdis.2018.11.006
Abstract: Mutational analysis is an efficient approach to identifying microbial gene function. Until recently, lack of an effective tool for Anaplasmataceae yielding reproducible results has created an obstacle to functional genomics, because surrogate systems, e.g., ectopic… read more here.
Keywords: analysis; gene function; mutational analysis; analysis gene ... See more keywords
High-Throughput Analysis and Engineering of Ribozymes and Deoxyribozymes by Sequencing.
Sign Up to like & getrecommendations! Published in 2020 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.0c00546
Abstract: ConspectusRibozymes and deoxyribozymes are catalytic RNA and DNA, respectively, that catalyze chemical reactions such as self-cleavage or ligation reactions. While some ribozymes are found in nature, a larger variety of ribozymes and deoxyribozymes have been… read more here.
Keywords: throughput; analysis; mutational analysis; ribozyme deoxyribozyme ... See more keywords
Comprehensive Mutational Analysis of the Lasso Peptide Klebsidin.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00148
Abstract: Antibiotic resistance is a growing threat to public health, making the development of antibiotics of critical importance. One promising class of potential new antibiotics are ribosomally synthesized and post-translationally modified peptides (RiPPs), which include klebsidin,… read more here.
Keywords: lasso peptide; analysis lasso; klebsidin; mutational analysis ... See more keywords
Can Mutational Analysis Be Used To Assist Structure Determination of Peptides?
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b11302
Abstract: Mutational analysis is widely used to study the relationship between sequence and structure of proteins and peptides. It is often assumed that substituting a proline with another amino acid "locks" the peptide bond in the… read more here.
Keywords: analysis used; mutational analysis; used assist; assist structure ... See more keywords
Deep mutational analysis reveals functional trade-offs in the sequences of EGFR autophosphorylation sites
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1803598115
Abstract: Significance Phosphorylation of tyrosine residues in the cytoplasmic tail of the epidermal growth factor receptor (EGFR) by its kinase domain propagates a rich variety of information downstream of growth factor binding. The amino acid sequences… read more here.
Keywords: mutational analysis; tyrosine; tail; phosphorylation ... See more keywords
Mutational analysis of the flavinylation and binding motifs in two protein targets of the flavin transferase ApbE.
Sign Up to like & getrecommendations! Published in 2019 at "FEMS microbiology letters"
DOI: 10.1093/femsle/fnz252
Abstract: Many flavoproteins belonging to three domain types contain an FMN residue linked through a phosphoester bond to a threonine or serine residue found in a conserved seven-residue motif. The flavinylation reaction is catalyzed by a… read more here.
Keywords: flavinylation; analysis flavinylation; mutational analysis; binding motifs ... See more keywords
Diagnostic accuracy of mutational analysis along the Müllerian tract to detect ovarian cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2022-003911
Abstract: Objective Ovarian cancer is known for its poor prognosis, which is mainly due to the lack of early symptoms and adequate screening options. In this study we evaluated whether mutational analysis in cervicovaginal and endometrial… read more here.
Keywords: diagnostic accuracy; ovarian cancer; mutational analysis; cancer ... See more keywords
Mutational Analysis of EXT1in a Chinese Family Affected by Hereditary Multiple Osteochondroma
Sign Up to like & getrecommendations! Published in 2021 at "BioMed Research International"
DOI: 10.1155/2021/8888948
Abstract: Objectives To discuss the mutational features and their relationships with disease in a family with hereditary multiple osteochondroma (HMO) from Guangxi Province (GXBB-1 family), China. Methods Genomic DNA and total mRNA were extracted from peripheral… read more here.
Keywords: gxbb family; mutational analysis; family; multiple osteochondroma ... See more keywords