Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21833-w
Abstract: Multidimensional fitness landscapes provide insights into the molecular basis of laboratory and natural evolution. To date, such efforts usually focus on limited protein families and a single enzyme trait, with little concern about the relationship… read more here.
Keywords: multiple catalytic; cooperative mutational; conformational dynamics; pervasive cooperative ... See more keywords
Trans-allelic mutational effects at the Peg3 imprinted locus
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DOI: 10.1371/journal.pone.0206112
Abstract: How one allele interacts with the other for the function of a gene is not well understood. In this study, we tested potential allelic interaction at the Peg3 imprinted locus with several mutant alleles targeting… read more here.
Keywords: peg3 dmr; imprinted locus; mutational effects; trans allelic ... See more keywords