Substrate-Specific Screening for Mutational Hotspots Using Biased Molecular Dynamics Simulations
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DOI: 10.1021/acscatal.7b02634
Abstract: Prediction of substrate-specific mutational hotspots for enzyme engineering is a complex and computationally intensive task. This becomes particularly challenging when the available crystal structures have no ligand, bind a distant homologue of the desired substrate,… read more here.
Keywords: screening mutational; molecular dynamics; mutational hotspots; ligand ... See more keywords
Human Kinases Display Mutational Hotspots at Cognate Positions Within Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing"
DOI: 10.1142/9789813207813_0039
Abstract: The discovery of driver genes is a major pursuit of cancer genomics, usually based on observing the same mutation in different patients. But the heterogeneity of cancer pathways plus the high background mutational frequency of… read more here.
Keywords: kinases display; kinase paralogs; display mutational; human kinases ... See more keywords
Some Mutational Hotspots May Be APOBEC3A-Associated Passengers.
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DOI: 10.1158/2159-8290.cd-rw2019-102
Abstract: Cancer-associated mutational hotspots may be created by APOBEC3A's preference for certain structures. read more here.
Keywords: may apobec3a; mutational hotspots; associated passengers; hotspots may ... See more keywords