The mutational landscape of cold agglutinin disease: CARD11 and CXCR4 mutations are correlated with lower hemoglobin levels
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26205
Abstract: AUTHOR CONTRIBUTIONS Musa Yilmaz, Hagop Kantarjian, Naval Daver, Farhad Ravandi designed the study, analyzed the data, and wrote the paper. Musa Yilmaz, Sherry Pierce, Naval Daver, collected and analyzed the data. Sanam Loghavi, Keyur Patel,… read more here.
Keywords: mutational landscape; disease card11; cold agglutinin; agglutinin disease ... See more keywords
Mutational landscape and clinical outcome of pediatric acute myeloid leukemia with 11q23/ KMT2A rearrangements
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5026
Abstract: Alterations of 11q23/KMT2A are the most prevalent cytogenetic abnormalities in acute myeloid leukemia (AML) and the prognostic significance of 11q23/KMT2A‐rearranged AML based on various translocation partners varies among different studies. However, few studies evaluated the… read more here.
Keywords: myeloid leukemia; 11q23 kmt2a; acute myeloid; kmt2a ... See more keywords
The mutational landscape and prognostic indicators of pseudomyxoma peritonei originating from the ovary
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Cancer"
DOI: 10.1002/ijc.33460
Abstract: Pseudomyxoma peritonei (PMP) is a rare disorder with unique pathological and genetic changes. Although several studies have reported the clinical features and mutational changes of PMP that originates from the appendix, few studies on PMP… read more here.
Keywords: mutational landscape; originating ovary; pseudomyxoma peritonei; landscape ... See more keywords
Mutational landscape of receptor guanylyl cyclase C: Functional analysis and disease‐related mutations
Sign Up to like & getrecommendations! Published in 2020 at "IUBMB Life"
DOI: 10.1002/iub.2283
Abstract: Guanylyl cyclase C (GC‐C) is the receptor for the heat‐stable enterotoxin, which causes diarrhea, and the endogenous ligands, guanylin and uroguanylin. GC‐C is predominantly expressed in the intestinal epithelium and regulates fluid and ion secretion… read more here.
Keywords: mutational landscape; analysis; landscape receptor; guanylyl cyclase ... See more keywords
The Mutational Landscape of Metastatic Castration-sensitive Prostate Cancer: The Spectrum Theory Revisited.
Sign Up to like & getrecommendations! Published in 2021 at "European urology"
DOI: 10.1016/j.eururo.2020.12.040
Abstract: BACKGROUND Emerging data suggest that metastasis is a spectrum of disease burden rather than a binary state, and local therapies, such as radiation, might improve outcomes in oligometastasis. However, current definitions of oligometastasis are solely… read more here.
Keywords: mutational landscape; metastatic castration; prostate cancer; spectrum ... See more keywords
Mutational landscape of Gastric Adenocarcinoma in Latin America: A genetic approach for precision medicine
Sign Up to like & getrecommendations! Published in 2021 at "Genes and Diseases"
DOI: 10.1016/j.gendis.2021.04.002
Abstract: Abstract Latin-America (LATAM) is the second region in gastric cancer incidence; gastric adenocarcinoma (GA) represents 95% of all cases. We provide a mutational landscape of GA highlighting a) germline pathogenic variants associated with hereditary GA,… read more here.
Keywords: precision medicine; medicine; mutational landscape; latin america ... See more keywords
Mutational landscape of Zika virus strains worldwide and its structural impact on proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.05.039
Abstract: Zika virus (ZIKV) has spread globally and has been linked to the onset of microcephaly and other brain abnormalities. The ZIKV genome consists of an ~10.7 kb positive-stranded RNA molecule that encodes three structural (C, prM… read more here.
Keywords: zikv proteins; landscape zika; mutational landscape; impact ... See more keywords
Incorporating the mutational landscape of SARS-COV-2 variants and case-dependent vaccination rates into epidemic models
Sign Up to like & getrecommendations! Published in 2022 at "Infectious Disease Modelling"
DOI: 10.1016/j.idm.2022.02.003
Abstract: Coronavirus Disease (COVID-19), which began as a small outbreak in Wuhan, China in December 2019, became a global pandemic within months due to its high transmissibility. In the absence of pharmaceutical treatment, various non-pharmaceutical interventions… read more here.
Keywords: time; vaccination; vaccination rates; vaccine ... See more keywords
Applying next-generation sequencing to unravel the mutational landscape in viral quasispecies
Sign Up to like & getrecommendations! Published in 2020 at "Virus Research"
DOI: 10.1016/j.virusres.2020.197963
Abstract: Abstract Next-generation sequencing (NGS) has revolutionized the scale and depth of biomedical sciences. Because of its unique ability for the detection of sub-clonal variants within genetically diverse populations, NGS has been successfully applied to analyze… read more here.
Keywords: unravel mutational; mutational landscape; viral quasispecies; next generation ... See more keywords
The mutational landscape of human somatic and germline cells.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-03822-7
Abstract: Over the course of an individual's lifetime, normal human cells accumulate mutations1. Here we compare the mutational landscape in 29 cell types from the soma and germline using multiple samples from the same individuals. Two… read more here.
Keywords: mutational landscape; human somatic; landscape; cell types ... See more keywords
Mutational landscape of RNA-binding proteins in human cancers
Sign Up to like & getrecommendations! Published in 2018 at "RNA Biology"
DOI: 10.1080/15476286.2017.1391436
Abstract: ABSTRACT RNA Binding Proteins (RBPs) are a class of post-transcriptional regulatory molecules which are increasingly documented to be dysfunctional in cancer genomes. However, our current understanding of these alterations is limited. Here, we delineate the… read more here.
Keywords: driver rbps; mutational landscape; binding proteins; rna binding ... See more keywords