The sculpting of somatic mutational landscapes by evolutionary forces and their impacts on aging‐related disease
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13275
Abstract: Aging represents the major risk factor for the development of cancer and many other diseases. Recent findings show that normal tissues become riddled with expanded clones that are frequently driven by cancer‐associated mutations in an… read more here.
Keywords: somatic mutational; mutational landscapes; disease; cancer ... See more keywords
The role of coevolutionary signatures in protein interaction dynamics, complex inference, molecular recognition, and mutational landscapes.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2019.03.024
Abstract: Evolution imposes constraints at the interface of interacting biomolecules in order to preserve function or maintain fitness. This pressure may have a direct effect on the sequence composition of interacting biomolecules. As a result, statistical… read more here.
Keywords: protein interaction; recognition; biology; mutational landscapes ... See more keywords