Low mutational load in pediatric medulloblastoma still translates into neoantigens as targets for specific T-cell immunotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2019.06.009
Abstract: BACKGROUND Medulloblastoma is the most common malignant brain tumor in childhood and adolescence. Although some patients present with distinct genetic alterations, such as mutated TP53 or MYC amplification, pediatric medulloblastoma is a tumor entity with… read more here.
Keywords: mutational load; low mutational; medulloblastoma; specific cell ... See more keywords
PUB053 Panel Based Hybrid Capture Sequencing Assay to Correlate Mutational Load with Response to Immunotherapy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2016.11.2023
Abstract: www.newoncology.de Background: The use of immune checkpoint inhibitors has shown promise in lung cancer as well as several other tumor types. However, two of their limitations are the overall relatively low response rate as well… read more here.
Keywords: mutational load; immunotherapy; response; hybrid capture ... See more keywords
Fitness, Mutational Load, and Eugenics
Sign Up to like & getrecommendations! Published in 2025 at "Philosophy of Science"
DOI: 10.1017/psa.2025.10137
Abstract: Eugenic arguments are not a thing of the past. In 2016 geneticist Michael Lynch published an article in Genetics arguing that human mental and physical performance is declining at a rate of 1% per generation.… read more here.
Keywords: mutational load; load; philosophy; fitness mutational ... See more keywords
The mutational load in natural populations is significantly affected by high primary rates of retroposition
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2013043118
Abstract: Significance The phenomenon of retroposition (the reintegration of reverse-transcribed RNA into the genome) has been well studied in comparisons between species and has been identified as a source of evolutionary innovation. However, less attention has… read more here.
Keywords: mutational load; natural populations; retroposition mutational; negative effects ... See more keywords
High mutational load gets a response
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.364.6439.447-i
Abstract: Cancer Cancers harbor many genetic mutations. Defects in DNA mismatch repair prevent tumors from repairing certain types of DNA damage and lead to a hypermutable genomic state known as microsatellite instability (MSI). Some tumors with… read more here.
Keywords: science; high mutational; response; load gets ... See more keywords
Mutational load may predict risk of progression in patients with Barrett’s oesophagus and indefinite for dysplasia: a pilot study
Sign Up to like & getrecommendations! Published in 2019 at "BMJ Open Gastroenterology"
DOI: 10.1136/bmjgast-2018-000268
Abstract: Background and aims Mutational load (ML) has been shown to help risk-stratify those that may progress from non-dysplastic Barrett’s oesophagus (BE) to dysplastic disease. Management of patients with BE and indefinite for dysplasia (BE-IND) is… read more here.
Keywords: risk; mutational load; pilot study; dysplasia ... See more keywords
Impact of Chemical-Induced Mutational Load Increase on Immune Checkpoint Therapy in Poorly Responsive Murine Tumors
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-17-1091
Abstract: A recurring historic finding in cancer drug development is encouraging antitumor effects observed in tumor-bearing mice that fail to translate into the clinic. An intriguing exception to this pattern is immune checkpoint therapy, as the… read more here.
Keywords: immune checkpoint; checkpoint therapy; mutational load; cancer ... See more keywords
Abstract PD6-03: Distribution of microsatellite instability, tumor mutational load, and PD-L1 status in molecularly profiled invasive breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs17-pd6-03
Abstract: Background: Recent data indicate a promising response to immune check point blockade (ICB) in patients with breast cancer. Pembrolizumab, a humanized monoclonal antibody against programmed death 1 (PD-1) receptor and one of several ICB agents… read more here.
Keywords: mutational load; breast; tumor mutational; breast cancer ... See more keywords
Abstract PD8-11: APOBEC3 contributes to mutational load in breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs17-pd8-11
Abstract: Breast cancer results in large part from the accumulation of multiple mutations in premalignant cells, which provide a molecular basis for genetic diversity. This genetic diversity in premalignant cells allows selection for increased proliferation and… read more here.
Keywords: cancer; contributes mutational; mutational load; breast cancer ... See more keywords
Association of Tumor Microenvironment T-cell Repertoire and Mutational Load with Clinical Outcome after Sequential Checkpoint Blockade in Melanoma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-18-0226
Abstract: Order matters. Clinical outcomes were associated with the mutational and neoantigen loads, and T-cell infiltrates, of pretreatment samples in a checkpoint blockade phase II trial only if nivolumab is used before ipilimumab, but not the… read more here.
Keywords: checkpoint; neoantigen; mutational load; load ... See more keywords
Mutational load in carotid body tumor
Sign Up to like & getrecommendations! Published in 2019 at "BMC Medical Genomics"
DOI: 10.1186/s12920-019-0483-x
Abstract: BackgroundCarotid body tumor (CBT) is a rare neoplasm arising from paraganglion located near the bifurcation of the carotid artery. There is great intra-tumor heterogeneity, and CBT development could be associated with both germline and somatic… read more here.
Keywords: body tumor; mutational load; carotid; cbt ... See more keywords