Enriching productive mutational paths accelerates enzyme evolution
Sign Up to like & getrecommendations! Published in 2024 at "Nature Chemical Biology"
DOI: 10.1038/s41589-024-01712-3
Abstract: Darwinian evolution has given rise to all the enzymes that enable life on Earth. Mimicking natural selection, scientists have learned to tailor these biocatalysts through recursive cycles of mutation, selection and amplification, often relying on… read more here.
Keywords: evolution; kemp eliminase; paths accelerates; enriching productive ... See more keywords
Mutational Paths with Sequence-Based Models of Proteins: From Sampling to Mean-Field Characterization.
Sign Up to like & getrecommendations! Published in 2022 at "Physical review letters"
DOI: 10.1103/physrevlett.130.158402
Abstract: Identifying and characterizing mutational paths is an important issue in evolutionary biology, with potential applications to bioengineering. We here propose an algorithm to sample mutational paths, which we benchmark on exactly solvable models of proteins… read more here.
Keywords: sequence based; mutational paths; sequence; models proteins ... See more keywords