Cycloaddition enabled mutational profiling of 5-vinyluridine in RNA.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc00043e
Abstract: We report the detection of 5-vinyluridine (5-VUrd) in RNA at single nucleotide resolution via mutational profiling. Maleimide cycloadducts with 5-VUrd in RNA cause a stop in primer extension during reverse transcription, and the full-length cDNA… read more here.
Keywords: rna; profiling vinyluridine; mutational profiling; enabled mutational ... See more keywords
Improving the prediction of acute myeloid leukaemia outcomes by complementing mutational profiling with ex vivo chemosensitivity
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Haematology"
DOI: 10.1111/bjh.16432
Abstract: Refractoriness to induction therapy and relapse after complete remission are the leading causes of death in patients with acute myeloid leukaemia (AML). This study focussed on the prediction of response to standard induction therapy and… read more here.
Keywords: risk; myeloid leukaemia; mutational profiling; acute myeloid ... See more keywords
Mutational profiling of Chinese ROS1 positive non-small cell lung cancer patients with required resistant to crizotinib by next generation sequencing.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e13120
Abstract: e13120Background: The ROS1 rearrangement has been identified in 1%-2% of NSCLC cases, these patients would benefit from the inhibitor of crizotinib. But the resistance to crizotinib inevitably developed in the patients with ROS1+ NSCLC and… read more here.
Keywords: crizotinib; resistance crizotinib; mutational profiling; profiling chinese ... See more keywords
Accurate detection of chemical modifications in RNA by mutational profiling (MaP) with ShapeMapper 2.
Sign Up to like & getrecommendations! Published in 2018 at "RNA"
DOI: 10.1261/rna.061945.117
Abstract: Mutational profiling (MaP) enables detection of sites of chemical modification in RNA as sequence changes during reverse transcription (RT), subsequently read out by massively parallel sequencing. We introduce ShapeMapper 2, which integrates careful handling of… read more here.
Keywords: shapemapper; map shapemapper; map; profiling map ... See more keywords
Prioritizing mutational profiling for targeted therapy of lung adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of thoracic disease"
DOI: 10.21037/jtd.2019.02.29
Abstract: The Lung Cancer Mutation Consortium (LCMC) was launched as a cross-institutional effort to prospectively follow non-small cell lung cancer (NSCLC) patients across sixteen centers in the US, with a focus on genomic mutation profiles, in… read more here.
Keywords: lung; mutational profiling; prioritizing mutational; profiling targeted ... See more keywords
Mutational profiling of melanomas in patients from the southeast coast of China
Sign Up to like & getrecommendations! Published in 2020 at "Translational cancer research"
DOI: 10.21037/tcr-20-1871
Abstract: Melanoma is the most lethal form of skin cancer. Based on the anatomical site, it can be classified as cutaneous (with or without chronic sun-induced damage), acral, or mucosal (1). Cutaneous melanoma is the predominant… read more here.
Keywords: profiling; patients southeast; melanomas; melanomas patients ... See more keywords