Clinical and genomic characterization of mutational signatures across human cancers
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34402
Abstract: Mutational signatures, the generic patterns of mutations, are the footprints of both endogenous and exogenous factors that have influenced cancer development. To date, dozens of mutational signatures have been discerned through computational methods. However, the… read more here.
Keywords: cancer; related signature; clinical genomic; mutation ... See more keywords
Divergence of mutational signatures in association with breast cancer subtype
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23461
Abstract: Abnormal molecular processes occurring throughout the genome leave distinct somatic mutational patterns termed mutational signatures. Exploring the associations between mutational signatures and clinicopathological features can unravel potential mechanisms driving tumorigenic processes. read more here.
Keywords: cancer subtype; signatures association; divergence mutational; breast cancer ... See more keywords
Dissection of Cancer Mutational Signatures with Individual Components of Cigarette Smoking.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.3c00021
Abstract: Tobacco smoke delivers a complex mixture of hazardous and potentially hazardous chemicals. Some of these may induce the formation of DNA mutations, which increases the risk of various cancers that display characteristic patterns of accumulated… read more here.
Keywords: dissection cancer; tobacco; human cancers; mutational signatures ... See more keywords
Genomic Characterization Revealed PM2.5-Associated Mutational Signatures in Lung Cancer Including Activation of APOBEC3B.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c08092
Abstract: Fine particulate matter (PM2.5) exposure causes DNA mutations and abnormal gene expression leading to lung cancer, but the detailed mechanisms remain unknown. Here, analysis of genomic and transcriptomic changes upon a PM2.5 exposure-induced human bronchial… read more here.
Keywords: lung cancer; exposure; pm2 exposure; mutational signatures ... See more keywords
Quantification and Mapping of Alkylation in the Human Genome Reveal Single Nucleotide Resolution Precursors of Mutational Signatures
Sign Up to like & getrecommendations! Published in 2023 at "ACS Central Science"
DOI: 10.1021/acscentsci.2c01100
Abstract: Chemical modifications to DNA bases, including DNA adducts arising from reactions with electrophilic chemicals, are well-known to impact cell growth, miscode during replication, and influence disease etiology. However, knowledge of how genomic sequences and structures… read more here.
Keywords: damage; alkylation; single nucleotide; resolution ... See more keywords
Single base substitution and insertion/deletion mutational signatures in adult core binding factor acute myeloid leukemia
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DOI: 10.1038/s41375-022-01552-x
Abstract: TO THE EDITOR Single base substitutions (SBSs) and insertions/deletions (indels; IDs) arise through several mechanisms such as errors during DNA replication/repair and exposures to mutagens, with the different mutational processes occasionally generating specific mutational signatures.… read more here.
Keywords: cancer; runx1 runx1t1; aml; mutational signatures ... See more keywords
The repertoire of mutational signatures in human cancer
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-1943-3
Abstract: Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic mutational signature 1 . Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium 2 of… read more here.
Keywords: human cancer; cancer; base substitution; mutational signatures ... See more keywords
signeR: an empirical Bayesian approach to mutational signature discovery
Sign Up to like & getrecommendations! Published in 2017 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btw572
Abstract: Motivation: Mutational signatures can be used to understand cancer origins and provide a unique opportunity to group tumor types that share the same origins and result from similar processes. These signatures have been identified from… read more here.
Keywords: bayesian approach; number signatures; empirical bayesian; approach ... See more keywords
Mutational signatures and increased retrotransposon insertions in Xeroderma Pigmentosum variant skin tumors
Sign Up to like & getrecommendations! Published in 2022 at "Carcinogenesis"
DOI: 10.1101/2022.07.28.22277756
Abstract: Xeroderma Pigmentosum variant (XP-V) is an autosomal recessive disease with an increased risk to develop cutaneous neoplasms in sunlight exposed regions. These cells are deficient in the translesion synthesis DNA polymerase eta. Eleven skin tumors… read more here.
Keywords: xeroderma pigmentosum; skin tumors; pigmentosum variant; mutational signatures ... See more keywords
Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aao3130
Abstract: A signature event for organoids Human cancer genomes harbor cryptic mutational signatures that represent the cumulative effects of DNA damage and defects in DNA repair processes. Knowledge of how specific signatures originate could have a… read more here.
Keywords: origin mutational; crispr; signature; cancer ... See more keywords
Abstract CN05-01: DNA damage signatures and practical use
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-cn05-01
Abstract: A cancer genome is a historical account of the mutagenic activity that has occurred throughout the development of the tumor. Indeed, every mutation matters. While driver mutations were the main focus of cancer research for… read more here.
Keywords: cancer; dna damage; mutational signatures; nik zainal ... See more keywords