The prognostic impact of CDX2 correlates with the underlying mismatch repair status and BRAF mutational status but not with distant metastasis in colorectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "Virchows Archiv"
DOI: 10.1007/s00428-018-2360-y
Abstract: Loss of CDX2 expression has been proposed to be a prognostic biomarker in colorectal cancer (CRC) correlating with shorter overall (OS) and progression-free survival (PFS). Since metastatic disease, mismatch repair (MMR) deficiency, and the mutational… read more here.
Keywords: status; cdx2 expression; status braf; mutational status ... See more keywords
The gene mutational discrepancies between primary and paired metastatic colorectal carcinoma detected by next-generation sequencing
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-018-2742-1
Abstract: PurposeTo better understand the gene mutational status and heterogeneity between primary and metastatic CRC (mCRC) using a sensitive sequencing method.MethodsThe mutational status of EGFR, KRAS, NRAS, PIK3CA, ERBB2, BRAF, KIT, and PDGFRA was analyzed in… read more here.
Keywords: gene mutational; primary paired; mutational status; gene ... See more keywords
NLR and BRCA mutational status in patients with high grade serous advanced ovarian cancer
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DOI: 10.1038/s41598-021-90361-w
Abstract: Laboratory-markers of the systemic inflammatory-response, such as neutrophil/lymphocyte-ratio (NLR) have been studied as prognostic factors in several tumors but in OC-patients their role is still controversial and no data about the possible correlation with the… read more here.
Keywords: status; brca mutational; grade serous; serous advanced ... See more keywords
The mutational status of p53 can influence its recognition by human T-cells
Sign Up to like & getrecommendations! Published in 2017 at "OncoImmunology"
DOI: 10.1080/2162402x.2017.1285990
Abstract: ABSTRACT p53 was reported to be an attractive immunotherapy target because it is mutated in approximately half of human cancers, resulting in its inactivation and often accumulation in tumor cells. Peptides derived from p53 are… read more here.
Keywords: mutational status; status p53; recognition; influence ... See more keywords
P121 Surgical secondary cytoreduction in recurrent ovarian cancer patients with liver metastasis
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2019-esgo.184
Abstract: Introduction/Background To describe accurately the oncological outcomes after hepatic resection (HR) in recurrent ovarian carcinoma (ROC) evaluating clinic-pathological variables and mutational status of BRCA1/2. Although HR is considered a challenging situation in ROC patients, assessment… read more here.
Keywords: mutational status; patients liver; recurrent ovarian; phr pfs ... See more keywords
299 Precision oncology in surgery: patient selection for operable recurrent hepatic ovarian cancer
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2019-igcs.299
Abstract: Objectives To describe accurately the oncological outcomes after hepatic resection (HR) in recurrent ovarian carcinoma (ROC) evaluating clinic-pathological variables and mutational status of BRCA1/2. Although HR is considered a challenging situation in ROC patients, assessment… read more here.
Keywords: mutational status; recurrent; phr pfs; oncology ... See more keywords
Correlation of BRAF mutational status with clinical characteristics and survival outcomes of patients with ameloblastoma: the experience of 11 Italian centres
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2021-207527
Abstract: Aims Ameloblastoma is a rare odontogenic tumour with an aggressive local behaviour. Mutations in the mitogen-activated protein kinase pathway, namely BRAF V600E mutations, are a common finding. To date, there is no clear correlation between… read more here.
Keywords: italian centres; braf mutational; mutational status; status clinical ... See more keywords
Abstract LB-083: Targeting IRAK4 disrupts inflammatory pathways and tumor microenvironment in chronic lymphocytic leukemia regardless MYD88 mutational status
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-lb-083
Abstract: BACKGROUND & AIM. Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in Toll-like receptor (TLR) signal transduction and the innate immune response. Recruitment of IRAK4 to these receptors and its subsequent activation is facilitated… read more here.
Keywords: cll; mutational status; myd88 mutational; chronic lymphocytic ... See more keywords
Abstract IA08: Personalizing HNSCC treatment based on TP53 mutational status
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.aacrahns17-ia08
Abstract: Head and neck squamous cell carcinoma (HNSCC) is a leading cause of cancer deaths worldwide, and resistance to standard treatments with radiation/chemotherapy accounts for the majority of HNSCC deaths. Mutation of TP53 occurs in 60-85%… read more here.
Keywords: tp53 mutational; hnscc; mutational status; cancer ... See more keywords
Next-Generation Sequencing Targeted Chronic Lymphocytic Leukemia Panel: A Pilot Study
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DOI: 10.1182/blood-2020-139418
Abstract: Background: Rapid progress in next-generation sequencing (NGS) technologies make it possible to spell out the mutational status, the genetic and epigenetic variability of chronic lymphocytic leukemia (CLL). The identification of driver mutations allows us to… read more here.
Keywords: cll; mutational status; speakers bureau; honoraria speakers ... See more keywords
Machine learning modeling of genome-wide copy number alteration signatures reliably predicts IDH mutational status in adult diffuse glioma
Sign Up to like & getrecommendations! Published in 2021 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-021-01295-3
Abstract: Knowledge of 1p/19q-codeletion and IDH1/2 mutational status is necessary to interpret any investigational study of diffuse gliomas in the modern era. While DNA sequencing is the gold standard for determining IDH mutational status, genome-wide methylation… read more here.
Keywords: diffuse glioma; idh mutational; status; genome wide ... See more keywords