Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.38795
Abstract: We systematically and quantitatively evaluate whether endoplasmic reticulum (ER) proteostasis factors impact the mutational tolerance of secretory pathway proteins. We focus on influenza hemaggluttinin (HA), a viral membrane protein that folds in the host’s ER… read more here.
Keywords: temperature; tolerance; proteostasis; influenza ... See more keywords