ERK2 Mutations Affect Interactions, Localization, and Dimerization.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.3c00044
Abstract: The most frequent ERK2 (MAPK1) mutation in cancers, E322K, lies in the common docking (CD) site, which binds short motifs made up of basic and hydrophobic residues present in the activators MEK1 (MAP2K1) and MEK2… read more here.
Keywords: erk2 mutations; mutations affect; affect interactions; dimerization ... See more keywords
HER3 Mutations Affect Tumor Response to HER2-Targeted Therapies.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2021-093
Abstract: HER3 missense mutations can inhibit response of tumor cells to HER2-targeted therapies. read more here.
Keywords: response; her2 targeted; her3 mutations; targeted therapies ... See more keywords
MECP2 mutations affect ciliogenesis: a novel perspective for Rett syndrome and related disorders
Sign Up to like & getrecommendations! Published in 2020 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201910270
Abstract: Mutations in MECP2 cause several neurological disorders of which Rett syndrome (RTT) represents the best‐defined condition. Although mainly working as a transcriptional repressor, MeCP2 is a multifunctional protein revealing several activities, the involvement of which… read more here.
Keywords: ciliogenesis; affect ciliogenesis; rett syndrome; mutations affect ... See more keywords