The interaction between common genetic mutations in AML and the immune landscape: mechanisms and implications for immune response
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1635111
Abstract: Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy driven by diverse genetic mutations that shape tumor progression, immune evasion, and clinical outcomes. While molecular profiling has improved AML classification, the precise impact of specific… read more here.
Keywords: aml immune; immune landscape; genetic mutations; interaction common ... See more keywords
Towards a Better Understanding of Cohesin Mutations in AML
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.00867
Abstract: Classical driver mutations in acute myeloid leukemia (AML) typically affect regulators of cell proliferation, differentiation, and survival. The selective advantage of increased proliferation, improved survival, and reduced differentiation on leukemia progression is immediately obvious. Recent… read more here.
Keywords: selective advantage; understanding cohesin; mutations aml; cohesin mutations ... See more keywords
NPM 1 Mutations in AML—The Landscape in 2023
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DOI: 10.3390/cancers15041177
Abstract: Simple Summary The nucleophosmin 1 (NPM1) gene is mutated in approximately one-third of newly diagnosed acute myeloid leukemia (AML) cases. NPM1mutated AML (NPM1mut-AML) has been reclassified as a distinct entity in the 2022 World Health… read more here.
Keywords: landscape 2023; aml; leukemia; aml landscape ... See more keywords