Dominating the Negative: How DNMT3A Mutations Contribute to AML Pathogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2016.12.008
Abstract: Somatic mutations in DNMT3A are one of the most prevalent genetic abnormalities found in acute myeloid leukemia (AML) patients. A new study by Guryanova et al. sheds mechanistic insight into how the most common DNMT3A variant… read more here.
Keywords: dnmt3a mutations; dominating negative; dnmt3a; negative dnmt3a ... See more keywords
Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aba3064
Abstract: Joint analysis of genomic and transcriptomic data reveals diverse noncoding mutation landscapes in five types of pediatric cancers. Interpreting the function of noncoding mutations in cancer genomes remains a major challenge. Here, we developed a… read more here.
Keywords: deregulation cis; contribute deregulation; noncoding mutations; diverse noncoding ... See more keywords