BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL
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DOI: 10.1158/2159-8290.cd-21-1566
Abstract: BCL10 mutations in diffuse large B-cell lymphoma (DLBCL) fall into two classes, with both conferring BTK inhibitor resistance but only truncation mutations conferring MALT1 dependency, suggesting use of these mutation classes as precision therapy biomarkers. read more here.
Keywords: precision therapy; mutations define; bcl10 mutations;
Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2016.67.5264
Abstract: Purpose Adenoid cystic carcinomas (ACCs) represent a heterogeneous group of chemotherapy refractory tumors, with a subset demonstrating an aggressive phenotype. We investigated the molecular underpinnings of this phenotype and assessed the Notch1 pathway as a… read more here.
Keywords: subgroup; mutations define; notch1 mutations; metastasis ... See more keywords