Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-25222-0
Abstract: Aedes aegypti is the primary urban mosquito vector of viruses causing dengue, Zika and chikungunya fevers –for which vaccines and effective pharmaceuticals are still lacking. Current strategies to suppress arbovirus outbreaks include removal of larval-breeding… read more here.
Keywords: aedes aegypti; vgsc; mutations domains; evolution vgsc ... See more keywords
Multiple mutations on α, β and γ domains of streptokinase lead to the generation of highly efficient cysteine analogues with promising features.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201024666221124151623
Abstract: BACKGROUND Streptokinase, one of the most widely used thrombolytic medicines, is a favorable protein for site-specific PEGylation as it lacks any cysteine residues in its amino acid sequence; however, any changes in the protein´s structure… read more here.
Keywords: multiple mutations; mutations domains; cysteine analogues; activity ... See more keywords