Identification of Activating Mutations in the Transmembrane and Extracellular Domains of EGFR
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DOI: 10.1021/acs.biochem.2c00384
Abstract: The epidermal growth factor receptor (EGFR) is frequently mutated in human cancer, most notably non-small-cell lung cancer and glioblastoma. While many frequently occurring EGFR mutations are known to confer constitutive EGFR activation, the situation is… read more here.
Keywords: identification activating; mutations egfr; activating mutations; domains egfr ... See more keywords
TP53 co-mutations in EGFR mutated patients in NSCLC stage IV: A strong predictive factor of ORR, PFS and OS in EGFR mt+ NSCLC
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DOI: 10.18632/oncotarget.27430
Abstract: Introduction: The impact of TP53 co-mutations in EGFR mutated patients on PFS and OS is controversial. Different classifications of TP53 mutations with respect to functional and potential clinical impact have been published. Therefore, we retrospectively… read more here.
Keywords: egfr mutated; mutations egfr; tp53 mutations; orr pfs ... See more keywords