Aging: Somatic Mutations, Epigenetic Drift and Gene Dosage Imbalance.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2016.11.006
Abstract: Aging involves a progressive decline of metabolic function and an increased incidence of late-onset degenerative disorders and cancer. To a large extent, these processes are influenced by alterations affecting the integrity of genome architecture and,… read more here.
Keywords: mutations epigenetic; gene dosage; somatic mutations; aging somatic ... See more keywords
Concurrent mutations in other epigenetic modulators portend better prognosis in BCOR-mutated myelodysplastic syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2019-206132
Abstract: Introduction The role of single mutations has been extensively studied myelodysplastic syndromes (MDS), but the impact of genetic aberrations in the context of other mutations is less well understood. BCOR is an epigenetic transcriptional corepressor.… read more here.
Keywords: mutations epigenetic; epigenetic modulators; prognosis; concurrent mutations ... See more keywords