Insight into ponatinib resistance mechanisms in rhabdomyosarcoma caused by the mutations in FGFR4 tyrosine kinase using molecular modeling strategies.
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DOI: 10.1016/j.ijbiomac.2019.05.138
Abstract: Novel efficacious treatment of Rhabdomyosarcoma (RMS) with less toxicity has yet to emerge. Genomic analysis of RMS has reported that the receptor tyrosine kinase FGFR4 is highly expressed and frequently mutated in the tumor tissue.… read more here.
Keywords: molecular modeling; modeling strategies; mutations fgfr4; resistance mechanisms ... See more keywords