Mutations of the glycine cleavage system genes possibly affect the negative symptoms of schizophrenia through metabolomic profile changes
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DOI: 10.1111/pcn.12628
Abstract: Hypofunction of N‐methyl‐D‐aspartate receptors (NMDAR) may contribute to the pathophysiology of schizophrenia (SCZ). Recently, the glycine cleavage system (GCS) was shown to affect NMDAR function in the brain. GCS functional defects cause nonketotic hyperglycinemia, the… read more here.
Keywords: mutations glycine; glycine cleavage; cleavage system; system genes ... See more keywords