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   Articles with "mutations homologous" as a keyword



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The prevalence of gene mutations in homologous recombination repair pathways in Japanese patients with metastatic castration‐resistant prostate cancer in real‐world clinical practice: The multi‐institutional observational ZENSHIN study

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recommendations! Published in 2022 at "Cancer Medicine"

DOI: 10.1002/cam4.5333

Abstract: Metastatic castration‐resistant prostate cancer (mCRPC) is a genetically heterogeneous disease with a poor prognosis. The prevalence of mutations in homologous recombination repair (HRR) pathway genes, including BRCA1/2, as well as treatment patterns and clinical outcomes,… read more here.

Keywords: prostate cancer; resistant prostate; castration resistant; metastatic castration ... See more keywords
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A Systematic Review and Meta-Analysis on the Prognostic Value of BRCA Mutations, Homologous Recombination Gene Mutations, and Homologous Recombination Deficiencies in Cancer

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recommendations! Published in 2022 at "Journal of Oncology"

DOI: 10.1155/2022/5830475

Abstract: Patients with BRCA1/2 mutations (BRCAm), loss-of-function mutations in other homologous recombination repair (HRRm) genes, or tumors that are homologous recombination deficiency positivity (HRD+) demonstrate a robust response to PARPi therapy. We conducted a systematic literature… read more here.

Keywords: oncology; recombination; hrd; mutations homologous ... See more keywords
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Platinum-based chemotherapy for pancreatic cancer: impact of mutations in the homologous recombination repair and Fanconi anemia genes

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recommendations! Published in 2022 at "Therapeutic Advances in Medical Oncology"

DOI: 10.1177/17588359221083050

Abstract: Background: Mutations in homologous recombination (HR) and Fanconi anemia (FA) genes may predispose to pancreatic cancer (PC) and enable the prediction of sensitivity to platinum-based chemotherapy. FOLFIRINOX is a standard treatment option for non-selected PC… read more here.

Keywords: therapy; platinum; mutations homologous; fanconi anemia ... See more keywords