SARS-CoV-2 N gene mutations impact detection by clinical molecular diagnostics: reports in two cities in the United States
Sign Up to like & getrecommendations! Published in 2021 at "Diagnostic Microbiology and Infectious Disease"
DOI: 10.1016/j.diagmicrobio.2021.115468
Abstract: Nasal and nasopharyngeal swab specimens tested by the Cepheid Xpert Xpress SARS-CoV-2 were analyzed by whole-genome sequencing based on impaired detection of the N2 target. Each viral genome had at least one mutation in the… read more here.
Keywords: detection; gene mutations; mutations impact; cov gene ... See more keywords
Germline IKZF1 mutations and their impact on immunity: IKAROS-associated diseases and pathophysiology
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2021.1901582
Abstract: ABSTRACT Introduction: The transcription factor IKAROS and IKAROS family members are critical for the development of lymphocyte and other blood cell lineages. Germline heterozygous IKZF1 mutations have been described in primary immunodeficiency as well as… read more here.
Keywords: impact immunity; ikzf1 mutations; mutations impact; associated diseases ... See more keywords
Common framework mutations impact antibody interfacial dynamics and flexibility
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1120582
Abstract: Introduction With the flood of engineered antibodies, there is a heightened need to elucidate the structural features of antibodies that contribute to specificity, stability, and breadth. While antibody flexibility and interface angle have begun to… read more here.
Keywords: framework mutations; impact antibody; framework; common framework ... See more keywords
SARS-CoV-2 Mutations and Their Impact on Diagnostics, Therapeutics and Vaccines
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.815389
Abstract: With the high rate of COVID-19 infections worldwide, the emergence of SARS-CoV-2 variants was inevitable. Several mutations have been identified in the SARS-CoV-2 genome, with the spike protein as one of the mutational hot spots.… read more here.
Keywords: mutations impact; diagnostics therapeutics; therapeutics vaccines; cov mutations ... See more keywords