Re: "Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease".
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31169
Abstract: Studies of somatic mutations have historically focused on those occurring during carcinogenesis, but recent research suggests functional mutations can accumulate in the absence of cancer. Zhu and colleagues recently published an extensive analysis of exome… read more here.
Keywords: hepatic clonal; mutations increase; increase hepatic; somatic mutations ... See more keywords
EZH2 mutations increase the heterogeneity of chromatin states in lymphoma
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3003211
Abstract: A recent study in PLoS Biology used simultaneous measurements of histone modifications in single cells to reveal that EZH2 gain-of-function mutations profoundly reprogram chromatin states in B-cell lymphoma, while also increasing their cell–cell heterogeneity. read more here.
Keywords: biology; ezh2 mutations; mutations increase; chromatin states ... See more keywords