Mutations induce conformational changes in folliculin C-terminal domain: possible cause of loss of guanine exchange factor activity and Birt-Hogg-Dubé syndrome
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DOI: 10.1080/07391102.2016.1188728
Abstract: Mutations induce conformational changes in folliculin C-terminal domain: possible cause of loss of guanine exchange factor activity and Birt-Hogg-Dubé syndrome S. Verma, C. Tyagi, S. Goyal, B. Pandey, S. Jamal, A. Singh and A. Grover*… read more here.
Keywords: terminal domain; mutations induce; changes folliculin; folliculin terminal ... See more keywords
Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis
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DOI: 10.1158/0008-5472.can-22-0834
Abstract: Comprehensive proteogenomic and in silico analyses of a vast number of VUSs identify a novel set of oncogenic and druggable mutations in the well-characterized RET oncogene. read more here.
Keywords: calcium binding; ablating mutations; induce constitutive; mutations induce ... See more keywords
Myelodysplastic Syndrome Splicing Factor Mutations Induce R-Loops.
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DOI: 10.1158/2159-8290.cd-rw2018-025
Abstract: Mutations in SRSF2 and U2AF35 trigger replication stress and ATR activation via R-loop formation. read more here.
Keywords: induce loops; mutations induce; splicing factor; factor mutations ... See more keywords
PIK3CA Mutations Induce Neuronal Hyperactivity during Glioma Formation.
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DOI: 10.1158/2159-8290.cd-rw2020-019
Abstract: Two glioma driver mutations in PIK3CA promote neuronal hyperactivity via distinct mechanisms. read more here.
Keywords: glioma; induce neuronal; mutations induce; neuronal hyperactivity ... See more keywords