Multi-layered proteomic analyses decode compositional and functional effects of cancer mutations on kinase complexes
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17387-y
Abstract: Rapidly increasing availability of genomic data and ensuing identification of disease associated mutations allows for an unbiased insight into genetic drivers of disease development. However, determination of molecular mechanisms by which individual genomic changes affect… read more here.
Keywords: proteomic analyses; layered proteomic; multi layered; cancer ... See more keywords
Landscape of drug-resistance mutations in kinase regulatory hotspots
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbaa108
Abstract: More than 48 kinase inhibitors (KIs) have been approved by Food and Drug Administration. However, drug-resistance (DR) eventually occurs, and secondary mutations have been found in the previously targeted primary-mutated cancer cells. Cancer and drug… read more here.
Keywords: drug resistance; drug; mutations kinase; resistance mutations ... See more keywords