Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain
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DOI: 10.1093/femsyr/foy042
Abstract: Hsp104 is a hexameric AAA + ATPase and protein disaggregase found in yeast, which can be potentiated via mutations in its middle domain (MD) to counter toxic phase separation by TDP-43, FUS and α-synuclein connected to devastating… read more here.
Keywords: potentiating hsp104; mutations middle; activity via; hsp104 activity ... See more keywords