CALR frameshift mutations in MPN patient-derived iPSCs accelerate maturation of megakaryocytes.
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DOI: 10.1016/j.stemcr.2021.09.019
Abstract: Calreticulin (CALR) mutations are driver mutations in myeloproliferative neoplasms (MPNs), leading to activation of the thrombopoietin receptor and causing abnormal megakaryopoiesis. Here, we generated patient-derived CALRins5- or CALRdel52-positive induced pluripotent stem cells (iPSCs) to establish… read more here.
Keywords: derived ipscs; frameshift mutations; calr frameshift; mpn patient ... See more keywords