A quantification method of somatic mutations in normal tissues and their accumulation in pediatric patients with chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123241119
Abstract: Significance “Rare somatic mutations” are present in a small fraction of DNA molecules at as low as one in 107 to 108 bp in normal tissues, and are extremely difficult to detect. EcoSeq was developed… read more here.
Keywords: method somatic; normal tissues; mutations normal; quantification method ... See more keywords
Mutations in normal tissues—some diagnostic and clinical implications
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DOI: 10.1186/s12916-020-01763-y
Abstract: It has long been known that mutations are at the core of many diseases, most notably cancer. Mutational analysis of tissues and fluids is useful for cancer and other disease diagnosis and management. The prevailing… read more here.
Keywords: normal tissues; mutations normal; tissues diagnostic; clinical implications ... See more keywords