iPS cell generation-associated point mutations include many C > T substitutions via different cytosine modification mechanisms
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DOI: 10.1038/s41467-024-49335-5
Abstract: Genomic aberrations are a critical impediment for the safe medical use of iPSCs and their origin and developmental mechanisms remain unknown. Here we find through WGS analysis of human and mouse iPSC lines that genomic… read more here.
Keywords: generation; point mutations; mutations observed; ips cell ... See more keywords