No evidence that HLA genotype influences the driver mutations that occur in cancer patients
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DOI: 10.1007/s00262-021-03028-w
Abstract: The major histocompatibility (MHC) molecules are capable of presenting neoantigens resulting from somatic mutations on cell surfaces, potentially directing immune responses against cancer. This led to the hypothesis that cancer driver mutations may occur in… read more here.
Keywords: genotype; mutations occur; mhc; cancer ... See more keywords
PLCG2 C2 domain mutations co-occur with BTK and PLCG2 resistance mutations in chronic lymphocytic leukemia undergoing ibrutinib treatment
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DOI: 10.1038/leu.2017.110
Abstract: PLCG2 C2 domain mutations co-occur with BTK and PLCG2 resistance mutations in chronic lymphocytic leukemia undergoing ibrutinib treatment read more here.
Keywords: plcg2; occur btk; mutations occur; domain mutations ... See more keywords
Somatic CLL mutations occur at multiple distinct hematopoietic maturation stages: documentation and cautionary note regarding cell fraction purity
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DOI: 10.1038/leu.2017.343
Abstract: Somatic CLL mutations occur at multiple distinct hematopoietic maturation stages: documentation and cautionary note regarding cell fraction purity read more here.
Keywords: somatic cll; occur multiple; mutations occur; distinct hematopoietic ... See more keywords
The expanding landscape of ‘oncohistone’ mutations in human cancers
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DOI: 10.1038/s41586-019-1038-1
Abstract: Mutations in epigenetic pathways are common oncogenic drivers. Histones, the fundamental substrates for chromatin-modifying and remodelling enzymes, are mutated in tumours including gliomas, sarcomas, head and neck cancers, and carcinosarcomas. Classical ‘oncohistone’ mutations occur in… read more here.
Keywords: histone mutations; oncohistone mutations; mutations occur; expanding landscape ... See more keywords
Oncohistone Mutations Occur at Functional Sites of Regulatory ADP-ribosylation.
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DOI: 10.1158/0008-5472.can-22-0742
Abstract: Recent studies have identified cancer-associated mutations in histone genes that lead to the expression of mutant versions of core histones called oncohistones. Many oncohistone mutations occur at Asp and Glu residues, two amino acids known… read more here.
Keywords: growth; occur functional; oncohistone mutations; adprylation ... See more keywords
Immune Pressure on Polymorphous Influenza B Populations Results in Diverse Hemagglutinin Escape Mutants and Lineage Switching
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DOI: 10.3390/vaccines8010125
Abstract: Mutations arise in the genomes of progeny viruses during infection. Mutations that occur in epitopes targeted by host antibodies allow the progeny virus to escape the host adaptive, B-cell mediated antibody immune response. Major epitopes… read more here.
Keywords: amino acid; escape; immune pressure; mutations occur ... See more keywords