Abstract IA10: DNA repair mutations in ovarian carcinoma and relationship to therapeutic response
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DOI: 10.1158/1557-3125.dnarepair16-ia10
Abstract: Ovarian carcinomas with germline or somatic mutations in BRCA1 and BRCA2 are sensitive to platinum chemotherapy and to PARP inhibitors. The therapeutic role of damaging mutations in other homologous recombination genes is less certain. We… read more here.
Keywords: repair mutations; therapeutic response; mutations ovarian; dna repair ... See more keywords
Abstract AP11: IDENTIFYING FUNCTIONAL NONCODING SOMATIC MUTATIONS IN OVARIAN CANCER
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DOI: 10.1158/1557-3265.ovcasymp18-ap11
Abstract: Epithelial ovarian cancer (OC) is a heterogeneous disease that stratifies into different histologic subtypes including high-grade serous (HGSOC), clear cell (CCOC), endometrioid (EnOC) and mucinous (MOC) ovarian cancer. HGSOC is the most common, and each… read more here.
Keywords: histotype; ovarian cancer; somatic mutations; cancer ... See more keywords