BayeStab: Predicting effects of mutations on protein stability with uncertainty quantification
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4467
Abstract: Predicting protein thermostability change upon mutation is crucial for understanding diseases and designing therapeutics. However, accurately estimating Gibbs free energy change of the protein remained a challenge. Some methods struggle to generalize on examples with… read more here.
Keywords: bayestab predicting; uncertainty; predicting effects; bayestab ... See more keywords
Systematic evaluation of computational tools to predict the effects of mutations on protein stability in the absence of experimental structures
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbac025
Abstract: Abstract Changes in protein sequence can have dramatic effects on how proteins fold, their stability and dynamics. Over the last 20 years, pioneering methods have been developed to try to estimate the effects of missense… read more here.
Keywords: systematic evaluation; sequence; protein stability; absence experimental ... See more keywords
DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky300
Abstract: Abstract Proteins are highly dynamic molecules, whose function is intrinsically linked to their molecular motions. Despite the pivotal role of protein dynamics, their computational simulation cost has led to most structure-based approaches for assessing the… read more here.
Keywords: mutations protein; flexibility; stability; impact mutations ... See more keywords