The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and Biophysical Research Communications"
DOI: 10.1016/j.bbrc.2020.10.109
Abstract: The development of the SARS-CoV-2 pandemic has prompted an extensive worldwide sequencing effort to characterise the geographical spread and molecular evolution of the virus. A point mutation in the spike protein, D614G, emerged as the… read more here.
Keywords: sars cov; spike protein; d614g mutations; mutations sars ... See more keywords
Lung organoid simulations for modelling and predicting the effect of mutations on SARS-CoV-2 infectivity
Sign Up to like & getrecommendations! Published in 2021 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2021.03.020
Abstract: The global pandemic caused by the SARS-CoV-2 virus continues to spread. Infection with SARS- CoV-2 causes COVID-19, a disease of variable severity. Mutation has already altered the SARS-CoV-2 genome from its original reported sequence and… read more here.
Keywords: mutations sars; lung organoid; infectivity; cov infectivity ... See more keywords
Different mutations in SARS-CoV-2 associate with severe and mild outcome
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Antimicrobial Agents"
DOI: 10.1016/j.ijantimicag.2020.106272
Abstract: Introduction Genomic alterations in a viral genome can lead to either better or worse outcome and identifying these mutations is of utmost importance. Here, we correlated protein-level mutations in the SARS-CoV-2 virus to clinical outcome.… read more here.
Keywords: outcome; mutations sars; mild outcome; cov associate ... See more keywords
Emergence of genomic diversity and recurrent mutations in SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "Infection, Genetics and Evolution"
DOI: 10.1016/j.meegid.2020.104351
Abstract: Abstract SARS-CoV-2 is a SARS-like coronavirus of likely zoonotic origin first identified in December 2019 in Wuhan, the capital of China's Hubei province. The virus has since spread globally, resulting in the currently ongoing COVID-19… read more here.
Keywords: mutations sars; diversity; recurrent mutations; genomic diversity ... See more keywords
Non-synonymous mutations of SARS-CoV-2 leads epitope loss and segregates its variants
Sign Up to like & getrecommendations! Published in 2020 at "Microbes and Infection"
DOI: 10.1016/j.micinf.2020.10.004
Abstract: The non-synonymous mutations of SARS-CoV-2 isolated from across the world have been identified during the last few months. The surface glycoprotein spike of SARS-CoV-2 forms the most important hotspot for amino acid alterations followed by… read more here.
Keywords: mutations sars; synonymous mutations; loss; epitope loss ... See more keywords
Functional mutations of SARS-CoV-2: implications to viral transmission, pathogenicity and immune escape
Sign Up to like & getrecommendations! Published in 2022 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000002158
Abstract: Abstract The pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to major public health challenges globally. The increasing viral lineages identified indicate that the SARS-CoV-2 genome is… read more here.
Keywords: implications viral; sars cov; mutations sars; functional mutations ... See more keywords
Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis
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DOI: 10.1371/journal.ppat.1010627
Abstract: While SARS-CoV-2 continues to adapt for human infection and transmission, genetic variation outside of the spike gene remains largely unexplored. This study investigates a highly variable region at residues 203–205 in the SARS-CoV-2 nucleocapsid protein.… read more here.
Keywords: replication; nucleocapsid mutations; r203k g204r; pathogenesis ... See more keywords
Mutations of the SARS-CoV-2 Spike Glycoprotein Detected in Cats and Their Effect on Its Structure and Function
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.875123
Abstract: The high frequency of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) mutations and homology of the Angiotensin-Converting Enzyme-2 (ACE2) cell receptors in various hosts help the virus transcend species barriers. In this study, we investigated the… read more here.
Keywords: structure; spike glycoprotein; cov spike; glycoprotein detected ... See more keywords
Prediction of Recurrent Mutations in SARS-CoV-2 Using Artificial Neural Networks
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232314683
Abstract: Predicting SARS-CoV-2 mutations is difficult, but predicting recurrent mutations driven by the host, such as those caused by host deaminases, is feasible. We used machine learning to predict which positions from the SARS-CoV-2 genome will… read more here.
Keywords: recurrent mutations; prediction recurrent; sars cov; mutations sars ... See more keywords