SDHA Germline Mutations in SDH-Deficient GISTs: A Current Update
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DOI: 10.3390/genes14030646
Abstract: Loss of function of the succinate dehydrogenase complex characterizes 20–40% of all KIT/PDGFRA-negative GIST. Approximately half of SDH-deficient GIST patients lack SDHx mutations and are caused by a hypermethylation of the SDHC promoter, which causes… read more here.
Keywords: deficient gists; germline mutations; loss; sdha ... See more keywords