Clonal myelopoiesis in the UK Biobank cohort: ASXL1 mutations are strongly associated with smoking
Sign Up to like & getrecommendations! Published in 2020 at "Leukemia"
DOI: 10.1038/s41375-020-0896-8
Abstract: We sought to determine the significance of myeloid clonal hematopoiesis (CH) in the UK Biobank cohort ( n = 502,524, median age = 58 years). Utilizing SNP array ( n = 486,941) and whole exome sequencing data ( n… read more here.
Keywords: asxl1; smoking; biobank cohort; strongly associated ... See more keywords
DICER1 somatic mutations strongly impair miRNA processing even in benign thyroid lesions
Sign Up to like & getrecommendations! Published in 2019 at "Oncotarget"
DOI: 10.18632/oncotarget.26639
Abstract: The alteration of miRNA processing is a driver event in several tumors including thyroid cancer. In particular, somatic DICER1 mutations, reported in follicular-patterned lesions, are shared by benign as well as malignant tumors. In the… read more here.
Keywords: somatic mutations; dicer1 mutant; mirna processing; dicer1 somatic ... See more keywords