Phenylbutyrate rescues the transport defect of the Sec61α mutations V67G and T185A for renin
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DOI: 10.26508/lsa.202101150
Abstract: Using cellular models of the ADTKD–SEC61A1 causing mutations V67G and T185A, this study reveals specific aberrations of protein transport and calcium homeostasis as a potential pathogenic mechanism. The human Sec61 complex is a widely distributed… read more here.
Keywords: v67g t185a; mutations v67g; renin; protein transport ... See more keywords