Development of a genome-targeting mutator for the adaptive evolution of microbial cells.
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkab1244
Abstract: Methods that can randomly introduce mutations in the microbial genome have been used for classical genetic screening and, more recently, the evolutionary engineering of microbial cells. However, most methods rely on either cell-damaging agents or… read more here.
Keywords: mutator; development genome; adaptive evolution; microbial cells ... See more keywords
Conserved non-coding sequences and de novo Mutator insertion alleles are imprinted in maize.
Sign Up to like & getrecommendations! Published in 2022 at "Plant physiology"
DOI: 10.1093/plphys/kiac459
Abstract: Genomic imprinting is an epigenetic phenomenon in which differential allele expression occurs in a parent-of-origin dependent manner. Imprinting in plants is tightly linked to transposable elements (TEs), and it has been hypothesized that genomic imprinting… read more here.
Keywords: imprinting; coding sequences; conserved non; mutator ... See more keywords
Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abe7548
Abstract: IFN-I–NRF2 signaling imbalances drive immunometabolic dysfunction, inflammation, and premature aging in POLG mutator mice. Mitochondrial dysfunction is a key driver of inflammatory responses in human disease. However, it remains unclear whether alterations in mitochondria-innate immune… read more here.
Keywords: type interferon; mutator; dysfunction; dysfunction inflammation ... See more keywords
Entamoeba histolytica “mutator” strain with a high rate of genetic mutations assists the elucidation of drug resistance mechanisms
Sign Up to like & getrecommendations! Published in 2025 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01210-25
Abstract: ABSTRACT In drug discovery, target identification and elucidation of resistance mechanisms are essential. The pathogen strains resistant to a compound of interest are useful for these purposes. As the generation of drug-resistant strains is time-consuming… read more here.
Keywords: resistance; resistance mechanisms; rate; mutator ... See more keywords
DocFuzz: A Directed Fuzzing Method Based on a Feedback Mechanism Mutator
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Intelligent Systems"
DOI: 10.1155/int/7931792
Abstract: In response to the limitations of traditional fuzzing approaches that rely on static mutators and fail to dynamically adjust their test case mutations for deeper testing, resulting in the inability to generate targeted inputs to… read more here.
Keywords: mutator; feedback mechanism; methodology; docfuzz ... See more keywords
A Novel Mutator-Like Transposable Elements With Unusual Structure and Recent Transpositions in Barley (Hordeum vulgare)
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.904619
Abstract: Mutator-like transposable elements (MULEs) represent a unique superfamily of DNA transposons as they can capture host genes and cause higher frequency of mutations in some eukaryotes. Despite their essential roles in plant evolution and functional… read more here.
Keywords: like transposable; barley; transposable elements; mutator like ... See more keywords
Epistasis between mutator alleles contributes to germline mutation spectrum variability in laboratory mice
Sign Up to like & getrecommendations! Published in 2024 at "eLife"
DOI: 10.7554/elife.89096
Abstract: Maintaining germline genome integrity is essential and enormously complex. Although many proteins are involved in DNA replication, proofreading, and repair, mutator alleles have largely eluded detection in mammals. DNA replication and repair proteins often recognize… read more here.
Keywords: mutator; mutation spectrum; germline mutation; mutator alleles ... See more keywords