Epistasis between mutator alleles contributes to germline mutation spectrum variability in laboratory mice
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DOI: 10.7554/elife.89096
Abstract: Maintaining germline genome integrity is essential and enormously complex. Although many proteins are involved in DNA replication, proofreading, and repair, mutator alleles have largely eluded detection in mammals. DNA replication and repair proteins often recognize… read more here.
Keywords: mutator; mutation spectrum; germline mutation; mutator alleles ... See more keywords