Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice
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DOI: 10.1126/sciadv.abe7548
Abstract: IFN-I–NRF2 signaling imbalances drive immunometabolic dysfunction, inflammation, and premature aging in POLG mutator mice. Mitochondrial dysfunction is a key driver of inflammatory responses in human disease. However, it remains unclear whether alterations in mitochondria-innate immune… read more here.
Keywords: type interferon; mutator; dysfunction; dysfunction inflammation ... See more keywords