SERIneALanine Killer: SPT promiscuity inhibits tumour growth via intra-tumoral deoxysphingolipid production
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DOI: 10.1038/s41392-020-00401-6
Abstract: In a recent article in Nature, Muthusami et al. highlight the promiscuity of serine palmitoyltransferase (SPT) for non-essential amino acids under low serine conditions, illustrating a previously unappreciated mechanism for inhibition of tumour growth— increased… read more here.
Keywords: alanine; muthusami; tumour growth; serine ... See more keywords