Multiple zinc ions maintain the open conformation of the catalytic site in the DNA mismatch repair endonuclease MutL from Aquifex aeolicus
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13050
Abstract: The DNA mismatch repair endonuclease MutL consists of N‐terminal ATPase and C‐terminal endonuclease domains. The endonuclease domain binds zinc ion, although the ion seems not to function as a catalytic metal ion. Here, we solved… read more here.
Keywords: endonuclease; dna mismatch; zinc; mutl ... See more keywords
Biochemical characterization of mismatch-binding protein MutS1 and nicking endonuclease MutL from a euryarchaeon Methanosaeta thermophila.
Sign Up to like & getrecommendations! Published in 2019 at "DNA repair"
DOI: 10.1016/j.dnarep.2019.01.005
Abstract: In eukaryotes and most bacteria, the MutS1/MutL-dependent mismatch repair system (MMR) corrects DNA mismatches that arise as replication errors. MutS1 recognizes mismatched DNA and stimulates the nicking endonuclease activity of MutL to incise mismatch-containing DNA.… read more here.
Keywords: endonuclease; nicking endonuclease; muts1 mutl; mutl ... See more keywords
Regulation of the MLH1–MLH3 endonuclease in meiosis
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DOI: 10.1038/s41586-020-2592-2
Abstract: During prophase of the first meiotic division, cells deliberately break their DNA 1 . These DNA breaks are repaired by homologous recombination, which facilitates proper chromosome segregation and enables the reciprocal exchange of DNA segments… read more here.
Keywords: endonuclease; dna; recombination intermediates; mutl ... See more keywords
Binding of the regulatory domain of MutL to the sliding β-clamp is species specific
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz115
Abstract: Abstract The β-clamp is a protein hub central to DNA replication and fork management. Proteins interacting with the β-clamp harbor a conserved clamp-binding motif that is often found in extended regions. Therefore, clamp interactions have… read more here.
Keywords: clamp binding; regulatory domain; clamp; mutl ... See more keywords
The Putative Endonuclease Activity of MutL Is Required for the Segmental Gene Conversion Events That Drive Antigenic Variation of the Lyme Disease Spirochete
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.888494
Abstract: The Lyme disease spirochete Borrelia burgdorferi, encodes an elaborate antigenic variation system that promotes the ongoing variation of a major surface lipoprotein, VlsE. Changes in VlsE are continual and always one step ahead of the… read more here.
Keywords: antigenic variation; lyme disease; mutl; variation ... See more keywords